eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-12-22 13 4 2379 2385 10.13005/bbra/2409 17446 article S. Ahmed 1,4 Ehab M. Attalla 2,5 M. E. Abdelwanis 4 Y. Saddeek 3 E. Shaaban 3 Nizam Uddin Farooqui 6 Department of physics, Rabigh college of science and arts king abdulaziz university,21911Rabigh, Saudi Arabia. Radiotherapy and Nuclear Medicine Department, National Cancer Institute, Cairo University, Cairo, Egypt. Department of physics Alazhar university Assiut branch Assiut Egypt. Department of radiotherapy and nuclear medicine south Egypt cancer institute Assiut university Assiut Egypt. Children Cancer Hospital, Cairo, Egypt. Department of Biological Sciences, Rabigh college of science and arts king abdulaziz university,21911Rabigh, Saudi Arabia. This work significantly observes the suitable of algorithms by comparing the dose calculation of breast and chest tumorsusing Clarkson, Convolution, Superposition and Fast Superposition algorithms in three-dimensional Conformal Radiotherapy (3D-CRT). Thirteenpost-operativebreast  casesand fifteen cancer chest patients were taken in this work. Treatment plans were createdusing 6 and 15 MV Photon beam qualitywith the CMS XiO treatment planning system (Computerized Medical System, St. Louis, MO). Statistical analysis was done by relating the mean relative difference, conformity index, and homogeneity index for target structures. The percentage of differencenoted between algorithms were9.4%, recorded with a low density point in case of breast. Superposition and fast superposition algorithm were presentedvery good results in both cases in view of the mean relative variancesusing a prescribed dose with four algorithms andthe lowest relative variableusing a given dose in different treatment techniques PTV. Superposition algorithm exposed good calculations in all techniques. Clarkson algorithm showed monotonically variation in the dose calculation points and histogram parameters. The other three algorithms are shown approximately similar results. we found from  the dosimetric results aconsiderable differenceamongfour algorithms.Conferring to this study, the algorithms varied.Significant upkeep must be occupied when calculating treatment plans, as the selection of the dose computation algorithm may affected on treatment planning as well as clinical effects. https://www.biotech-asia.org/vol13no4/prediction-of-dose-calculation-of-breast-and-chest-tumors-using-different-algorithms/ Algorithm; chest tumors; cancer breast; homogeneity index; treatment planning system