eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-09-25 13 3 1515 1521 10.13005/bbra/2294 15965 article Bijan Yazdi 1 Alireza Jahangiri Fard 2 Saber Akhtaran 3 Mohammad Khalili 4 Behnam Mahmoodiyeh 1 Department of Anesthesia and Critical Care , Arak University of Medical Sciences , Arak , Iran. Fellowship of Cardiac Anesthesia, Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) ,Shahid Beheshti University of Medical Science, Tehran, Iran. Aneshtesiologist , Arak University of Medical Sciences , Arak , Iran. Department of anesthesia and critical care ,Anesthesiologist,Arak University of Medical Science , Arak ,Iran. The occurrence of toxicity in various organs was examined since volatile anesthetics have been used clinically. Among the complications the liver toxicity is very important. Due to the effects of N-Acetyl Cysteine (NAC), we decided to conduct a study to assess liver function in patients undergoing anesthesia with isoflurane and received NAC to evaluate its effects on the liver complications of these anesthetics. In this double-blind clinical trial, 68 patients between 20 to 60 years old candidate for elective surgery with a time duration between 1 to 3 hours (except surgeries on the liver and biliary tract) were enrolled and randomly divided into two groups, N-acetylcysteine and control. To check liver function, the levels of AST, ALT, LDH, PT, aPTT and INR was measured in the preoperative, 1 hour and 24 hours after surgery. The results of the study showed that there was significant difference between the levels of ALT (p=0.0001), AST (p=0.0001), and LDH (p=0.0001) between two groups. Heart rate was also significantly different between groups (p=0.0001) but the difference in systolic (p=0.096) and diastolic (p=0.174) blood pressure was not significant. N-acetyl cysteine is an antioxidant medication and its effects on excreting organs such as the kidneys and liver is frequently evaluated. In this study, n-acetyl cysteine could significantly reduce liver enzyme levels after administration of isoflurane, compared to the control group.

https://www.biotech-asia.org/vol13no3/effect-of-n-acetyl-cysteine-on-liver-function-in-general-anesthesia-with-isoflurane/ Key Words: Acetylcysteine Isoflurane Liver Toxicity.